Dr. Sofia Guerra is a specialist in the safety, security, and assurance of complex digital systems. As Director at Themistoclea Ltd, she provides strategic and technical leadership in the development of robust assurance frameworks for high-stakes industries. Her expertise spans nuclear safety, AI governance, and regulatory frameworks for digital infrastructure. Before founding Themistoclea and as a partner at Adelard LLP, she guided the team’s work on transformative technologies like computer verification, and AI, which are now critical to the trustworthiness and operational success of engineering companies globally.
She has advised the U.S. Nuclear Regulatory Commission on risk-informed, performance-based safety justifications and played a key role in advancing AI assurance in the nuclear sector. She led the first AI sandboxing project in the nuclear industry, collaborating with the UK Office for Nuclear Regulation (ONR) and the Environment Agency to develop E3S cases for AI-based systems. She supported ONR in reviewing its approach to regulating AI in safety-critical applications. Her expertise is recognized internationally—she works with the IAEA on the safe deployment of AI in nuclear applications, serves on the IAEA International Network on Innovation steering committee, and contributes to the BSI ART/1 Artificial Intelligence standards committee.
Beyond AI and nuclear safety, Sofia has been at the forefront of safety and assurance case methodologies, including the widely adopted Claims-Arguments-Evidence (CAE) approach, which originated at Adelard. She has led major modernization and new-build projects in the nuclear industry, assessing control and instrumentation (C&I) systems, evaluating digital safety cases, and shaping regulatory guidance. She has served as an Independent Safety Auditor for UK defense projects and was registered as a software expert with the MHRA, assessing medical device software.
Her work has influenced safety, security, and assurance approaches across multiple industries, with methodologies that have been adopted internationally. Sofia's ability to merge hands-on technical expertise with strategic leadership has made her a recognized thought leader in the industry. Her contributions have helped companies in the nuclear sector—and beyond—depend on trustworthy digital systems to navigate regulatory challenges, enhance operational safety, and leverage the power of AI and data analytics for future growth.
She has advised the U.S. Nuclear Regulatory Commission on risk-informed, performance-based safety justifications and played a key role in advancing AI assurance in the nuclear sector. She led the first AI sandboxing project in the nuclear industry, collaborating with the UK Office for Nuclear Regulation (ONR) and the Environment Agency to develop E3S cases for AI-based systems. She supported ONR in reviewing its approach to regulating AI in safety-critical applications. Her expertise is recognized internationally—she works with the IAEA on the safe deployment of AI in nuclear applications, serves on the IAEA International Network on Innovation steering committee, and contributes to the BSI ART/1 Artificial Intelligence standards committee.
Beyond AI and nuclear safety, Sofia has been at the forefront of safety and assurance case methodologies, including the widely adopted Claims-Arguments-Evidence (CAE) approach, which originated at Adelard. She has led major modernization and new-build projects in the nuclear industry, assessing control and instrumentation (C&I) systems, evaluating digital safety cases, and shaping regulatory guidance. She has served as an Independent Safety Auditor for UK defense projects and was registered as a software expert with the MHRA, assessing medical device software.
Her work has influenced safety, security, and assurance approaches across multiple industries, with methodologies that have been adopted internationally. Sofia's ability to merge hands-on technical expertise with strategic leadership has made her a recognized thought leader in the industry. Her contributions have helped companies in the nuclear sector—and beyond—depend on trustworthy digital systems to navigate regulatory challenges, enhance operational safety, and leverage the power of AI and data analytics for future growth.